TrustyMails is an API that can be integrated into your registration process to prevent users from signing up with a throwaway email.
TrustyMails is designed to detect email addresses or domain names that are commonly associated with temporary, disposable, or fake email providers. Such a service is useful for businesses or organizations that want to prevent fraud, spam, fraudulent or abusive users from registering for their services using temporary email accounts.
TrustyMails scans the Internet for new disposable domains and analyzes the domains that are sent to its API. It maintains an always up-to-date database that you can query.